Stromal CEACAM1 expression regulates colorectal cancer metastasis
نویسندگان
چکیده
Colorectal cancer metastasis to Ceacam1-/- livers is significantly impaired, compared with wild type livers, due to decreased endothelial cell survival, reduced tumor cell proliferation, diminished immune infiltration and altered chemokine expression. Ceacam1-/- myeloid-derived suppressor cells diminish metastatic burden, as confirmed by bone marrow transplantation and adoptive transfer experiments.
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2012